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TpiA is a key metabolic enzyme that affects virulence and resistance to aminoglycoside antibiotics through CrcZ in Pseudomonas aeruginosa

Patients are frequently identified with PD only in the presence of tremor and other symptoms, by which time 6080% of the substantia nigra (SN) dopamine neurons have been lost, which occurs 5 to 15 years after the start of neuronal degeneration (Sulzer et al., 2018) (see Figure 1)